Pathological features of myxopapillary ependymomas in lumbar spinal canal: report of two cases

Myxopapillary ependymoma almost only occurs in conus medullaris, cauda equine and terminal filament, and myxopapillary ependymoma has distinctive morphology and immunohistochemical phenotype. The article will discuss two rare cases report of myxopapillary ependymoma. The two cases occur in lumbar spinal canal, tumor cells arrange in well-differentiated blood vessels or around the mesenchymal axis of connective tissue without cells with the nipple radial structure, and have obvious micro-capsule structure. There are accumulated with lots of grume between blood vessels and tumor cells. And are abundant with interstitial blood vessels, and bleeding, collagen in focal mesenchyme, and hemosiderin deposition in small focus. Immunohistochemical markers, including GFAP, Vimentin, S-100, NSE, showed positive expression in tumor cells, AE1/AE3, EMA, Syn, CD34, D2-40, showed negative expression in tumor cells, the proliferation index of Ki-67 was less than 1%. And we will analysis the clinicopathological features, and diagnosis differential diagnostic of the lumbar spinal canal of Myxopapillary ependymomas.